Idiopathic pulmonary fibrosis (IPF) is assumed to be caused by aberrant tissue repair and remodeling following recurrent alveolar epithelial injury leading to a persistent and progressive disordered fibroproliferation1. The matrix metalloproteinases belong to the zinc dependent endoproteases that participate in extracellular matrix remodeling, wound healing, and angiogenesis and have been implicated in the pathogenesis of IPF2.
| Description | Catalog Number | Packaging |
|---|---|---|
| DZ-Lite MMP-7 CLIA Kit | DZ903A | 100 tests/kit Calibrator Set: 2 x 1 mL Control Set: 2 x 1 mL |
Background
Idiopathic pulmonary fibrosis (IPF) is assumed to be caused by aberrant tissue repair and remodeling following recurrent alveolar epithelial injury leading to a persistent and progressive disordered fibroproliferation1. The matrix metalloproteinases belong to the zinc dependent endoproteases that participate in extracellular matrix remodeling, wound healing, and angiogenesis and have been implicated in the pathogenesis of IPF2. MMP family expression are highly upregulated in IPF lungs. The protein expression level has also been found to be upregulated in lavage fluid and blood of IPF patients.
Assay Features
- Fully automated chemiluminescent immunoassay
- Highly sensitive with LOQ level of 0.182 ng/mL
- Wide dynamic ranges up to 30 ng/mL
- Good correlations with ELISA method: R2 > 0.94
- High throughput: up to 150 test/hour
References
- Raghu G et. Al. Am J Respir Crit Care Med 183(6):788–824 (2011)
- E. Vasarmid EXPERIMENTAL AND THERAPEUTIC MEDICINE 20: 2557-2560, 2020
Intended use
The DZ-Lite MMP-7 CLIA Kit is for the determination of MMP-7 concentration in Li-Heparin plasma and runs on the DZ-Lite Chemiluminescence Analyzer. For Research Use Only in the USA. Not for use in diagnostic procedures.